Phase III clinical trial for COVID-19 treatment
(completed Jan 2022)
This study was a randomized, double-blind, placebo-controlled study that took place at 20 clinical sites across India and enrolled 306 patients who had contracted COVID-19. In the NONS™ treatment group, the SARS-CoV-2 viral load was reduced by more than 94% within 24 hours of treatment, and by more than 99% in 48 hours, compared to participants using a saline nasal spray (placebo). The median time to a negative PCR test in this group was 4 days in the treatment group compared with 8 days in the control. More patients taking NONS™ were also asymptomatic by the end of the 16-day study compared to those taking placebo. Mild adverse events were observed in NONS participants (6.5%, nasal discomfort) compared to 2.7% in the placebo group.
Although the study was designed only to assess treatment, it also looked at infection rates of people in close contact with study participants: the NONS household infection rates remained stable, while infections in placebo households increased, hinting at a potential role in prevention (no statistics were run on the close contacts data).